Effervescent Tablets Line
Effervescent tablets are easy to consume due to this they are getting popular over other oral dosage forms. Effervescent tablets get break when they are put in water or juice which causes tablet to dissolve and form a solution. USFDA redefined the definition to Effervescent tablet is a tablet intended to be dissolved or dispersed in water before administration. Effervescent tablets consists of acids/acid salt, carbonates and hydrogen carbonates, flavour, sweetener, etc. which release carbon dioxide when it is added to water. Following chemical reaction takes place in effervescent tablets.
C6H8O7 (aq) + 3NaHCO3 (aq) → Na3C6H5O7 (aq) + 4H2O + 3CO2 (g) ↑
Citric acid + Sodium bicarbonate → Sodium citrate + Water + Carbon dioxide
The above reaction occurs due to presence of water, because water is one of the reaction product which accelerates the reaction, leading to difficulty in stopping the reaction. Due to this reason manufacturing and storage of effervescent product is planned by minimizing their contact with water [2,3].
Advantages of Effervescent Tablets
- Administered as palatable sparkling solution
- Readily absorbed because it has to consume in solution form.
- No need to swallow tablet
- Drugs that are unstable in aqueous solution when stored shows more stable state in effervescent granules or tablets forms.
- Better/good intestinal and stomach tolerance
- Large amount of active ingredients can be easily incorporated
- Better or accurate dosing.
- Rapid onset of action
- Good in taste
Limitations of Effervescent Tablets
- Excipients are costly
- Special production facilities is required.
- High sodium or potassium makes it inappropriate for patients with heart failure or cardiac insufficiency
- Difficult to formulate drugs with unpleasant taste sufficiently palatable as an effervescent product [4-7].
Excipients Used of Effervescent Tablets
Acids
• Citric acid
• Tartaric acid
• Adipic acid
• Fumaric acid
• Malic acid
Carbonates/Bicarbonates
• Sodium carbonate
• Potassium carbonate
• Calcium carbonate
• Sodium bicarbonate
• Potassium bicarbonate
Lubricants
• Sodium benzoate
• Polyethylene glycol
• Adipic acid
• Magnesium stearate
Inders
• Lactose
• Sorbitol
• Xylitol
• Dextrose
Sweeteners
• Acesulfame potassium
• Sodium saccharin
• Aspartame
• Sucralose
Flavours
• Powdarome Lemon
• Powdarome Orange
• Strawberry Flavour
• Tutti Frutti Flavo
